In this study, our results showed that co-treatment of BEZ235 and TSA resulted in greatly reduced Blc-2 protein expression in breast cancer cells, whereas Bax protein increased, in agreement with previous reports, which suggests that the ratio of Bcl-2/Bax is significant in the survival of drug-induced apoptosis in cancer cells, rather than Bcl-2 alone [40–42]. Here, BAX is linked to cancer.