A2780 cells exposed to exosomes from A2780 platinum-resistant subclones (i.e., CP70, C30, or C200) for 24 hours demonstrated at least a 50% reduction (P<0.05) in the expression of the epithelial markers dystroglycan, a cell-surface laminin receptor that links the cytoskeleton to the extracellular matrix in a variety of epithelial tissues [55, 56], E-cadherin, a cell-cell adhesion molecule and is down-regulated during EMT in numerous cancers [57, 58], and to a lesser extent EpCAM, the epithelial cell adhesion molecule expressed in epithelia and epithelial-derived neoplasms [59, 60]. This evidence concerns the gene DAG1 and cancer.