MUC4 and familial pancreatic carcinoma: As our and other studies in the literature have reported, pancreatic cancer cells can exploit the multi-functions of MUC4 to trigger malignant activities including proliferation [11, 12, 14, 16], resistance to apoptosis [14, 16], motility [16], invasiveness & neural invasion [15, 16, 17], angiogenesis [12, 16], metastasis [11–13, 15, 16], supressing immune [18], and chemoresistance [19–21].