The top four regulated proteins in a systematic review of CRC were 60-kDa heat shock protein (HSP60) and Nucleoside diphosphate kinase A (nm23-H1), up-regulated, and Selenium-binding protein 1 (SELENBP1) and Carbonic anhydrase I (CAI), down-regulated [200]. This evidence concerns the gene NME1 and colorectal carcinoma.