Along with this, in unsupervised hierarchal clustering, both the COLO 741 and COLO 699 cell lines cluster in the melanoma-specific branch (Figure 5b) and express skin-specific genes (eg. SILV, MLANA, DCT and SOX10) at such high levels that they are outliers when compared to all other annotated colorectal (Figure 5c) or lung cell lines (Figure 5d). This evidence concerns the gene PMEL and melanoma.