In this study, we found associations between five immunoregulatory gene SNPs and a higher NHL risk: four SNPs (IL-10 rs1800893, IL-1RN rs4251961, TNF-α rs1800630, and TNF-α rs2229094) were associated with an increased risk of overall NHL and DLBCL, while TNF- α rs1041981was associated with an increased risk of DLBCL only. This evidence concerns the gene IL10 and diffuse large B-cell lymphoma.