PRRT2 and cancer: Furthermore, GPCR, membrane Na+/Ca2+ exchanger, MLCK, and CAMK were decreased by hypermethylation in at least three cancer types, and most other genes (voltage-gated channel, PTK, Gq, PLCβ, Gs, PMCA, IP3R, PKA, SERCA, FAK2, PKC, IP3K and NOS) were downregulated in at least one cancer type (Figure 3).