These include cancer hallmarks of various types: oncogenes (BCL2, BRAF), caspases (CASP6/7), transcription factors (E2F3), cell cycle genes (CDC42, CDK2, CDKN2A), cancer related kinases (JAK2/3, MAPK4/6/14) and DNA repair genes (BRCA1, PARP1 and RAD50). The gene discussed is E2F3; the disease is cancer.