To date, 16 mutations in the MIP gene have been reported to be associate with autosomal dominant cataracts, including 10 missense mutations8, 13, 15, 16, 17, 18, 19, 20, 21; one acceptor splice-site mutation22; one donor splice-site mutation23; one deletion that causes a frameshift at 638delG14; one initiation codon mutation24; and two nonsense mutations25, 26. Here, MIP is linked to Autosomal dominant optic atrophy and cataract.