These polymorphisms associated with subclinical atherosclerosis in the general population were the following: ZHX2 [zinc fingers and homeoboxes 2] rs11781551, PINX1 [Pin2-interacting protein] rs6601530 and SLC17A4 [solute carrier family 17, member 4] rs4712972 as significant signals associated with carotid intima-media thickness (cIMT) and LRIG1 [leucine-rich repeats and immunoglobulin-like domains 1] rs17045031 and LDLR [low density lipoprotein receptor] rs6511720 as relevant polymorphisms involved in the presence of carotid plaques6. The gene discussed is ZHX2; the disease is atherosclerosis.