EGFR and non-small cell lung carcinoma: They appeared to transition from their original densely packed adherent layer of small cells to a spindle-like morphology with loss of intercellular adhesion, increased intercellular separation and increased formation of pseudopodia (Fig. 2c), suggestive of an EMT transition, a phenomenon that has been observed in non-small-cell lung cancer in the context of acquired resistance to EGFR inhibitors18.