Small animal PET/CT experiments comparing MDA-MB-231 (low PARP-1 expressing) and MDA-MB-468 (high PARP-1 expressing) xenograft tumours revealed PARP-1 mediated tumour uptake which could be blocked following pre-injection of either Olaparib or [19F]FTT. The gene discussed is PARP1; the disease is neoplasm.