Histone demethylase LSD1 (also referred to as KDM1A, AOF2, BHC110 or KIAA0601) was the first identified histone demethylase and is a member of the flavin adenine dinucleotide (FAD)-dependent amine oxidase family of demethylases.15 LSD1 inhibitors are a hot topic in the field of cancer therapy.23,24,42 However, few studies have investigated the effects of LSD1 inhibitors on the osteogenic differentiation of BMMSCs. This evidence concerns the gene MBD2 and cancer.