NFKB1 and neoplasm: The targets of ROS also include growth factors, inflammatory factors, and cell cycle regulators, including c-Myc, NF-κB, NF-E2-related factor 2 (Nrf2), hypoxia-inducible factor 1 (HIF-1α), and Protein Kinase C (PKC), and some of these factors are closely associated with multidrug resistance (MDR) in tumor [7].