Liraglutide can also contribute to decrease proteinuria in STZ-induced DN in Wistar rats by reducing the renal inflammation-mediated by NF-κB, TNF-α, MCP-1, IL-6, and INF-γ and by increasing eNOS phosphorylation, eNOS activity, and NO production [95]. This evidence concerns the gene IL6 and liver dysplastic nodule.