Indeed, it has been demonstrated that Periplocin reduces the levels of RA factors IL-6, Th2 cytokines (TGF-β1 and IL-13), Th1 (IFN-γ and IL-33), and Th17 (IL-22) and inhibits the expression of GATA3, T-bet, and C-Jun in LPS-induced splenocytes. This evidence concerns the gene IL22 and rheumatoid arthritis.