The t(9;22) chromosomal translocation in human leads to the formation of the BCR-ABL fusion gene that encodes a constitutively expressed and cytoplasmic-localized c-Abl kinase and has been shown to be critical for the development of chronic myelogenous leukemia (CML), acute lymphoid leukemia (ALL) and acute myelogenous leukemia (AML)3, 4, 5. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.