Overall, we found that IL-13 +1923C/T variant was associated with increased asthma susceptibility among Asians under each genetic model (T compared with C: OR=1.66, 95% CI=1.41–1.95, P<0.00001; TT compared with CC: OR=2.34, 95% CI=1.72–3.18, P<0.00001; CT compared with CC: OR=1.46, 95% CI=1.27–1.69, P<0.00001; TT + CT compared with CC: OR=1.74, 95% CI=1.45–2.08, P<0.00001; TT compared with CT + CC: OR=1.85, 95% CI=1.43–2.39, P<0.00001). This evidence concerns the gene IL13 and asthma.