CRH and asthma: 2011; Zhu et al. 2011; Liu et al. 2014). To date, few studies have defined the role of CRH in the regulation of pulmonary cellular immune and inflammatory responses (O'Kane et al. 2006). A previous study also demonstrated that preferences in CRH receptor expression could be associated with asthma severity (Drescher and Bai 2013).