For this reason, and given the history of heavy smoking, alcoholism and the fast growth of the tongue lesion, it was important to investigate the neoplastic potential of GCT using the immunohistochemical panel of S-100, vimentin, CD68, p53, Ki-67, E-cadherin, collagen IV and cytokeratin AE1/AE3 antibodies. This evidence concerns the gene MKI67 and granular cell tumor.