Reproductive abnormalities were noted in a small number of patients and included menstrual cycle disorders (67 [6.2%]), amenorrhea (female patients > 11 years, 38 [3.5%]), abnormal onset of puberty (93 [4.4%]), other abnormal reproductive conditions (49 [2.3%]), abnormal hormone levels including prolactin (21 [1%]), thyroid-stimulating hormone (145 [6.9%]), follicle-stimulating hormone (37 [1.8%]), testosterone (21 [1%]), and luteinizing hormone (35 [1.7%]). This evidence concerns the gene PRL and amenorrhea.