EGFR and neoplasm: This patient was treated with the second cycle infusion of CART-EGFR cells as soon as the CAR transgene copy number in PB dropped closely to the baseline level 8 weeks after the first cycle infusion, enabling CART cells effectively to persist in vivo for more than 24 weeks and the patient’s PR status to be sustained for 8.5 months, which may suggest that repeated infusions of CART cells could contribute to prolonging their persistence in vivo and providing a longer progression free survival in conditions where the targeted tumor responded to CART-EGFR cells.