EGFR and cholangiocarcinoma: In this manuscript, we report a case in which a patient with advanced unresectable/metastatic CCA achieved an 8.5-month partial response (PR) from the initial CART-EGFR treatment and obtained another 4.5-month PR when switched to the CD133-specific CART immunotherapy (registered as NCT02541370) after the resistance to CART-EGFR therapy was confirmed.