SOD1 and amyotrophic lateral sclerosis: For example, the polyclonal antibodies, USOD [16] and AJ10 [39], were raised against the region covering the protein interior of the natively folded SOD1 (Leu 42 - His 48 and Val 29 - Cys 57, respectively) (Fig. 8a), and both antibodies have been shown to immunostain the pathological inclusions in the spinal motor neurons of SOD1-ALS patients.