Their immunoreactivities were, furthermore, well correlated with the severity of degeneration in the model mice (lumbar spinal cord > cervical spinal cord > brainstem > cerebellum; Fig. 6a, Additional file 10: Figure S9A) and in the SOD1-ALS cases (ventral horn > dorsal horn; Fig. 7d). Here, SOD1 is linked to amyotrophic lateral sclerosis.