In another SOD1-ALS case with C111Y mutation (the case III-4 in [26]; Additional file 1: Table S1), the disease duration was exceptionally long (69 years), but the motor neurons in the ventral horn of the lumbar spinal cord exhibited immunoreactivity to anti-SOD1int antibody (Fig. 7c). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.