Two severe cardiac events occurred, in two distinct patients: i) an acute inferior and inferolateral myocardial infarction associated with diffuse coronaropathy treated with angioplasty and active stents in the intraventricular coronary artery, in a 34-year-old non-smoking man who concomitantly presented with mild kidney failure and hypertension and benefited from treatment with an ACE inhibitor; ii) a sinus arrest revealed by fatigue and malaise in a 22-year-old patient, that required a pace-maker. The gene discussed is ACE; the disease is hypertensive disorder.