The PROFESS results were different from those of the Perindopril Protection Against Recurrent Stroke Study Collaborative Group (PROGRESS) trial [36], in which treatment with the ACE inhibitor perindopril was associated with a 38% risk reduction in the occurrence of stroke, but the PROGRESS trial included only 762 diabetic patients and they were recruited much longer following the initial stroke than in the PROFESS trial. This evidence concerns the gene ACE and Stroke.