Thus a worse endothelial, arterial stiffness and cognitive profile of patients with diabetic foot could be a good marker of a higher degree of vascular involvement consistent with higher cardiovascular morbidity and metabolic cardiovascular pathogenic pathways of higher IL-6 and resistin plasma levels, and lower adiponectin plasma levels as previously reported [12] in subjects with diabetic foot. The gene discussed is IL6; the disease is diabetic foot.