Interestingly, the triggering of IL-6 trans-signaling, a process of aggregation of extracellular soluble IL-6 receptor and IL-6 associated with rheumatoid arthritis [44] and IBD [45], significantly increased WWC1 expression in human airway smooth muscle cells [46], suggesting a link between its expression and inflammatory diseases. Here, WWC1 is linked to rheumatoid arthritis.