Our results revealed that LCSE inhibited EGFR activity and protein expression in two NSCLC cells, concomitantly reduced the downstream Akt and Erk-1/-2 signaling, then downregulated Bcl-2, cyclin B1 and cyclin E and elevated Kip1/p27 and Bax. This evidence concerns the gene MAPK3 and non-small cell lung carcinoma.