COMP and obstructive sleep apnea syndrome: As shown in Fig. 3, increases in biomarkers of cartilage degradation (CTX-II and COMP) were significantly lower after 12 weeks in the male ch-OSA group, resulting in the following mean differences (95% CI) between placebo and ch-OSA: CTX-II 102.0 ng/mmol (12.6 to 191.4) (Fig. 3a) and COMP 2.1 U/L (0.3 to 3.9) (Fig. 3b).