To further confirm the ability of Gö6976 to revert the E- to N-cadherin switch and pro-metastatic phenotype of aggressive melanoma cells, the effect of this inhibitor was also tested on M4T2 cells that are derived from the cutaneous metastasis of a different melanoma patient and express high levels of N-cadherin but low levels of E-cadherin. This evidence concerns the gene CDH1 and melanoma.