To determine whether PKC inhibitors may affect the expression of E- and/or N-cadherin in metastatic melanoma cells, M2 cells were incubated with 1 μM Gö6976 or 1 μM Gö6983 for different periods of time (0, 1, 3, 24 and 48 h), then analyzed by western blot (Fig. 2). This evidence concerns the gene CDH2 and melanoma.