In contrast to the metastatic melanoma cells (M2 and M4T2 cell lines) (Figs. 2, 5a and 6a, d), Gö6976 inhibitor did not significantly affect the expression of E- or N-cadherins or the anchorage-independent growth in the primary melanoma cell line (I5) (Additional file 2). The gene discussed is CDH2; the disease is melanoma.