Regions of amplification at this locus encompassed a number of cancer-related genes including MDM4, Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2), and Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta (PIK3C2B) and several interleukin genes including IL10, IL19, IL20, and IL24 (Additional file 2: Table S2). This evidence concerns the gene MDM4 and cancer.