Microarray expression studies revealed upregulation of a number of vascular-specific receptor tyrosine kinases, including Tyrosine Kinase with Immunoglobulin like and EGF Like Domains 1 (TIE1), Kinase Insert Domain Receptor (KDR), SNF Related Kinase (SNRK), TEK Receptor Tyrosine Kinase (TEK), and Fms Related Tyrosine Kinase 1 (FLT1) in angiosarcomas [30]. The gene discussed is KDR; the disease is angiosarcoma.