BDNF and obesity due to melanocortin 4 receptor deficiency: For instance, Estonian adolescent girls bearing BDNF Val allele tended to have lower BMI than who bear Met allele; Croatian Caucasian children and adolescents who presented one or two Met alleles were prone to obesity; Puerto Rican women living in Boston with the GA or AA genotype were 50% more likely to be overweight compared to GG carriers [25–27].