SHANK2 and autism: The top associated da-DMSs, cg16069986 (p0-4/5 = 6.28 × 10−114, p4-8 < 2.25x10−308) and cg16312514(p0-4/5 = 1.67 × 10−106, p4-8 < 2.25x10−308) on chromosome 11q13.4 region were annotated in SHANK2. Mutations in this SHANK2 synaptic scaffolding gene have been associated with neurodevelopmental disorders and autism [13].