The present study aims to detect the UGT1A1 polymorphisms and expressions of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in the tumor tissues from gastric cancer patients and explore their relationships with the clinicopathological characteristics, hoping to provide guidance for targeted cancer therapies individually. The gene discussed is TUBB3; the disease is gastric cancer.