IL6 and viral infectious disease: Although module I included one of the hallmark-genes of LPS-stimulation, IL6, the hub genes in this module were BIRC3, encoding the baculoviral IAP repeat containing 3, and VPS37A, encoding vacuolar protein sorting 37 homolog A. BIRC3 was already implicated in the pro-inflammatory cytokine induction [92] and VPS37A in the inhibition of viral infection [93].