ERBB2 and neoplasm: However, the HER2-targeted HBc particles (ZHER2-ΔHBc) exhibited a significantly higher retention in the tumour (*p < 0.05) compared to the ΔHBc particles, so that we could conclude that our ZHER2-ΔHBc particles exhibited a significant enhancement in uptake in HER2-over-expressing tumours.