In the current study, we analysed the behaviour of recombinant HBc particles, specifically truncated recombinant HBc particles (ΔHBc) and HER2-targeting ZHER2 affibodies-expressing recombinant HBc particles (ZHER2-ΔHBc), in two HER2 (+++) MDA-MB-435-MLE tumour bearing NSG mice models, namely, IP and MFP tumour models. Here, ERBB2 is linked to neoplasm.