Fold-change upregulated genes in leprosy lesions are involved in autophagosome formation (33% of T-lep genes versus 5% of L-lep genes), regulation of autophagy (40% of T-lep versus 9% of L-lep), lysosomal function or pathways (2% of T-lep versus 0% of L-lep), and regulation of the lysosome (2% of T-lep versus 1% of L-lep) by way of the functional autophagy-lysosomal gene classification previously described by Jegga et al. (Fig 5A and S1 Table) [48]. This evidence concerns the gene LEP and leprosy.