KLF10 functions as a toggle by differential coupling of Sin3-histone deacetylase and P300/PCB-associated factor to integrate antagonistic signals regulating FOXP3, resulting in immune activation, and it also can directly bind to the TGF-β RII promoter in CD8(+)T cells, leading to enhanced gene expression and tumor immune response. The gene discussed is FOXP3; the disease is neoplasm.