Since hepatocytes express low level of MITA/STING, the enhanced HBV replication in MITA/STING-/- mice probably was due to the deficiency of MITA/STING in NPCs, as lack of MITA/STING would influence host innate immune response as well as DCs maturation, and defective antigen presentation of DCs consequently impaired the expansion of leukemia specific T cells and CTL response to control HBV replication. Here, STING1 is linked to leukemia.