In a Cox proportional hazards models adjusted for age, gender, PD staring year, healthcare insurance status, DM, hypertension, comorbidity score, visual disturbance, BMI, hemoglobin, albumin, log CRP, and baseline eGFR, middle school or lower education group, but not high school education group was shown to be an independent risk factor for development of peritonitis (adjusted HR, 1.61; 95% CI, 1.10–2.36; P = 0.015, Fig 3A) compared with the reference group. This evidence concerns the gene CRP and peritonitis.