CASP3 and synovial sarcoma: Cleaved caspase 3/7 induction is significantly increased over time in synovial sarcoma cell lines SYO-1 and MoJo following low dose treatment of the quisinostat/bortezomib combination, while only doxorubicin had a significant effect on the HEK293T cells, as measured by IncuCyteTM Kinetic Caspase-3/7 Apoptosis Assay Reagent (Fig 6B).