In addition, upregulation of the PI3K/AKT/mTOR growth signaling pathway as well as increased expression of the pro-apoptotic protein BCL-2 (B-cell lymphoma-2) are hallmarks of synovial sarcoma biology, together eliciting a proliferative and apoptosis-resistant phenotype [13, 14]. This evidence concerns the gene BCL2 and synovial sarcoma.