sPD-1 concentrations were significantly lower in the sepsis cohort compared to HC (1.3 ng/mL, IQR 0.6–5.8, vs 2.9 ng/mL, IQR 0.9–9.1, p = 0.01) but there was no significant difference compared to ICU controls (2.4 ng/mL, IQR 0.7–5, p = 0.2) or between ICU controls and HC (p = 0.17). The gene discussed is HOXD13; the disease is Sepsis.