sPD-1 concentrations did not differ significantly between subgroups according to old (severe sepsis-septic shock) or new (sepsis-septic shock) sepsis definitions (p = 0.2 and p = 0.7 respectively) or between 28 day survivors and non-survivors in the sepsis cohort (p = 0.9) and ICU controls (p = 0.7), nor did they correlate to markers of disease severity (data not shown). Here, HOXD13 is linked to Shock.