Three genes (SYT1, CPLX2, and CPLX1) were enriched in exocytosis and five genes (CCKBR, GABRA1, MCHR2, GRIN3A, and GABRA4) in neuroactive ligand receptor interaction pathway, sharing two common genes with GABA pathway (DNM1, GABRA1, and GABRA4), which plays a significant role in glioma cell growth and proliferation in GBM [48, 49]. Here, CPLX1 is linked to central nervous system cancer.