EGFR and neoplasm: Furthermore, four genes (MAP2K1, EIF4EBP1, MAPK8, and RPS6KB1) were enriched in ERBB signaling pathway, required for GBM stem cell proliferation [50, 51], and three genes (MAP2K1, MAPK8, and RPS6KB1) were enriched in NFAT pathway, promoting tumor angiogenesis [52, 53].