BIRC5 and cancer: Eleven genes (FBXO5, CDK2, TTK, CDC25C, NUSAP1, BUB1, MAD2L1, NEK2, CCNA2, BUB1B, and BIRC5) were shown to be enriched in mitosis regulation pathway, and three of them (CHEK1, CDC25C, and CDK2) were enriched in RB pathway as well, which plays a central role in the regulation of cancer cell proliferation [45].