Pugh et al. performed whole genome sequencing of peripheral blood DNA samples on 240 cases of NB patients, and found a few germline mutations including CHEK2 (c.433C > T, c.542G > A and c.539G > A), PINK1 (c.1040T > C and c.836G > A), BARD1(c.334C > T and c.1921C > T) and PALB2 (c.1684+1C > A) [12]. Here, CHEK2 is linked to neuroblastoma.