CD133-mediated temozolomide resistance in glioma cells was shown to be dependent on the activation of Notch and Shh pathways [21], while CD133 was shown to confer resistance to multiple chemotherapeutic agents via upregulation of CD90, CD44, nestin, Msi1 and MELK [20], and the Akt and NF-kB pathways [22]. The gene discussed is PROM1; the disease is central nervous system cancer.