Again, mRNA expression levels of PYGO2 and KDM5B were higher in Luminal, HER2+, and basal-like breast cancers, and ZMYND8 was higher in Luminal B and HER2+ subtypes compared with that in the normal-like subtype in the METABRIC dataset (Supplementary Figure S4B; p < 0.001). This evidence concerns the gene KDM5B and breast cancer.