ASXL3 and neoplasm: As shown in Figure 2A and Supplementary Table S10, we identified a total of 40 ASXL family mutations, consisting of 7 mutations of ASXL1, 17 mutations of ASXL2, and 16 mutations of ASXL3. One tumor sample (TCGA-BH-A0B9) had three missense mutations (D893H, E1006K, and G1198V) in the ASXL1 gene, and one sample (TCGA-AN-A046) had two nonsense mutations (R357* and R312*) in the ASXL2 gene.