Among the 11 most amplified/gained PHF genes, 7 (PYGO2, KDM5B, PHF20L1, ASH1L, PHF20, DIDO1, and ASXL1) likely had a higher frequency of gain/amplification in both Luminal and basal subtypes of breast cancer, and 4 of them (ZMYND8, BPTF, CREBBP, and FBXL19) were more commonly amplified/gained in Luminal, particularly Luminal B breast cancer, than in the normal-like subtype (Figure 1A, Supplementary Table S4). Here, PYGO2 is linked to breast cancer.