Of the remaining 8 genes, the differential expression of 4 genes, DPP4, BCAT1, CNTNAP4 and CDH3, each showed a trend towards predicting worse survival, and in combination, this 4-gene set correlated with earlier onset of metastatic disease compared with cases without expression changes in these genes (Figure 7A, p=0.0667). The gene discussed is CDH3; the disease is metastatic neoplasm.