Specifically, the upregulation of ZNF217 and TOP2B correlated with an earlier onset of CRPC (Figure 8B) in the study of Taylor et al. [82], and the combined upregulation of ZNF217 and downregulation of FOXO1 correlated with earlier CRPC onset and decreased survival in the provisional PC dataset from TCGA (http://cancergenome.nih.gov/) (Figure 8C). This evidence concerns the gene TOP2B and pachyonychia congenita.