EZH2 and pachyonychia congenita: The NOV gene, known to be transcriptionally downregulated by activated Src [70] and by a direct interaction between AR and the transcriptional repressor, EZH2, on the NOV promoter [71], may play a paradoxical role in promoting PC metastasis based on findings that its increased secretion by CRPC cells induces greater infiltration of pro-metastatic M2 macrophages [72].