Whereas androgen-activated AR blocks engagement by FOXO1 of promoter elements for apoptosis and cell cycle arrest genes [110], consistent with FOXO1’s role as a transcriptional repressor, AR-TOP2B complexes coordinately regulate gene expression (as shown by co-ChIP experiments) as well as androgen-induced double-strand breaks and gene rearrangements, correlating highly with TMPRSS2-ERG fusion-positive PC [86]. Here, AR is linked to pachyonychia congenita.