Further, to determine if CXCL12 suppression was a unique effect of BH3 mimetics on T265-2c cells or represented a more general response of MPNST cells, an additional NF1-derived (90-8) and a sporadic MPNST cell line (STS26T) were treated with AT101, ABT, OBX and SBX for 24h followed by qRT-PCR analysis of CXCL12. Here, NF1 is linked to malignant peripheral nerve sheath tumor.