[30, 31] HIF-1α expression in the tumor cells was suppressed by treatment of the cells with 0.5 μM emetine in the presence of CoCl2, which was used to mimic a hypoxia condition and by treatment of cells grown under the condition of 5% O2 hypoxia for 48 h (Figure 4B and Supplemental Figure S3C). The gene discussed is HIF1A; the disease is neoplasm.