Vascular endothelial growth factor (VEGF or VEGF-A) is one of the major proangiogenic factors of both physiological and pathological angiogenesis, and is consistently upregulated during diverse forms of pathological angiogenesis.5,6 The VEGF/VEGF receptor-2 (VEGFR-2)–targeting therapies, including neutralizing antibodies (bevacizumab and ranibizumab) and kinase inhibitors (sorafenib and sunitinib), have shown clinical benefits for cancer patients either as single agent or when combined with chemotherapy (reviewed in Ref. Here, VEGFA is linked to cancer.